CARM1

Across TCGA pan-cancer cohorts, CARM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CARM1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CARM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CARM1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where CARM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.880	0.476	.008	13	view →
GBM	DFS	Quartile	All	0.259	0.480	.011	10	view →
PDAC	OS	Quartile	III,IV	0.174	0.568	.019	8	view →
CCRCC	DFS	Tertile	III,IV	0.320	0.666	.004	7	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.948	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CARM1–LSCC (DFS)

Open the LSCC breakdown →