CARM1

Across TCGA patient cohorts, CARM1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARM1-associated genes across cancer lineages are ATM, PKC-b-II_pS660, and Rad50. Each is linked with CARM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARM1-to-partner and partner-to-CARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CARM1-low versus CARM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARM1→partner) and Y-score (partner→CARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.567	-2.571	<.001	.010	3	3
UCEC	PKC-b-II_pS660 →	-0.230	-1.807	.023	.025	3	2
UCEC	Rad50 →	-0.194	-2.986	.029	.035	3	2
UCEC	ERK2 →	+0.225	+1.847	.001	.008	3	1
UCEC	FOXO3a_pS318_S321 →	-0.119	-1.896	.009	.015	3	1
UCEC	INPP4B →	-0.266	-2.115	.025	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by CARM1 expression — UCEC

Explore this box plot interactively →