CARM1

Across TCGA cell cohorts, CARM1 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARM1-associated genes across cancer lineages are LRIT1, GML, and LGI1. Each is linked with CARM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARM1-to-partner and partner-to-CARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by CARM1-low versus CARM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARM1→partner) and Y-score (partner→CARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRIT1 →	+0.041	+5.269	<.001	<.001	3	2
BLOOD_Leukemia	GML →	+0.057	+4.152	.007	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1
BLOOD_Leukemia	KERA →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.067	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

LRIT1 by CARM1 expression — BLOOD_Leukemia

Explore this box plot interactively →