CARF

Across TCGA pan-cancer cohorts, CARF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CARF data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CARF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CARF expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and GBM are the cancer types where CARF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.962	0.559	.002	13	view →
LUAD	OS	Tertile	All	1.000	0.600	.019	7	view →
GBM	OS	Median	All	0.609	0.912	.020	6	view →
CCRCC	DFS	Tertile	II,III,IV	0.667	0.952	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CARF–LSCC (DFS)

Open the LSCC breakdown →