Across TCGA patient cohorts, CARD9 protein abundance is significantly associated with the RNA expression of many other genes, with 17,878 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CARD9-associated genes across cancer lineages are TLR8, LILRB1, and CD33. Each is linked with CARD9 in more than 8 cancer types. Because this analysis shows association rather than direction, both CARD9-to-partner and partner-to-CARD9 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD9→partner) and Y-score (partner→CARD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLR8 →	+1.051	+0.433	<.001	<.001	3	9
GBM	LILRB1 →	+0.942	+0.522	<.001	<.001	3	9
GBM	CD33 →	+0.836	+0.483	<.001	<.001	3	9
OV	MS4A6A →	+1.254	+0.486	<.001	<.001	3	9
CCRCC	BIN2 →	+1.090	+0.718	<.001	<.001	3	9
GBM	SIGLEC9 →	+1.022	+0.474	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,878 associations by consensus.

Exploration

CARD9 survival (RNA) · tumor vs normal (RNA) · all CARD9 data types