Across TCGA patient cohorts, CARD9 mutation is significantly associated with the RNA expression of many other genes, with 3,646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD9-associated genes across cancer lineages are RNASEK, SEC13, and PGAM1. Each is linked with CARD9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARD9-to-partner and partner-to-CARD9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD9→partner) and Y-score (partner→CARD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNASEK →	+0.464	+3.850	<.001	<.001	3	3
UCEC	SEC13 →	+0.378	+3.617	.001	.001	3	3
UCEC	PGAM1 →	+0.928	+3.445	<.001	<.001	3	3
UCEC	CTDP1 →	+0.318	+2.724	.009	.003	3	3
UCEC	VPS18 →	+0.678	+3.828	<.001	<.001	3	3
UCEC	PPP6R1 →	+0.492	+2.280	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

Exploration

CARD9 survival (RNA) · tumor vs normal (RNA) · all CARD9 data types