Across TCGA patient cohorts, CARD9 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD9-associated genes across cancer lineages are Di-Ras3, MEK1, and ATM. Each is linked with CARD9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARD9-to-partner and partner-to-CARD9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD9→partner) and Y-score (partner→CARD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.239	-3.446	<.001	.005	3	3
UCEC	MEK1 →	+0.465	+2.700	.003	.006	3	2
UCEC	ATM →	-0.582	-2.986	.003	.035	3	2
UCEC	Cyclin-B1 →	+0.606	+2.115	.013	.019	3	2
UCEC	ERK2 →	+0.227	+2.115	.006	.019	3	1
UCEC	Ku80 →	+0.300	+2.820	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

CARD9 survival (RNA) · tumor vs normal (RNA) · all CARD9 data types