Across TCGA cell cohorts, CARD9 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CARD9-associated genes across cancer lineages are DEFB133, APOL5, and BEND2. Each is linked with CARD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD9-to-partner and partner-to-CARD9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD9→partner) and Y-score (partner→CARD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DEFB133 →	+0.046	+6.357	<.001	<.001	3	1
BLOOD_Leukemia	APOL5 →	+0.018	+5.060	<.001	.001	3	1
BLOOD_Leukemia	BEND2 →	+0.023	+4.551	<.001	.004	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	OR6Y1 →	+0.009	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CCL15 →	+0.029	+4.276	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

CARD9 survival (RNA) · tumor vs normal (RNA) · all CARD9 data types