CARD8

Across TCGA cell cohorts, CARD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,582 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARD8-associated GO terms across cancer lineages are Constitutive heterochromatin formation, Negative regulation of calcium ion export across plasma membrane, and Mitotic cytokinesis. Each is linked with CARD8 in more than 11 cancer types. Because this analysis shows association rather than direction, both CARD8-to-partner and partner-to-CARD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Constitutive heterochromatin formation grouped by CARD8-low versus CARD8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD8→partner) and Y-score (partner→CARD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Constitutive heterochromatin formation →	+0.067	+0.748	.001	.001	3	12
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.079	+0.892	.007	.006	3	11
LUNG_NSCLC_LUSC	Mitotic cytokinesis →	+0.089	+1.342	.003	.001	3	9
LUNG_NSCLC_LUAD	Cell division →	+0.049	+0.716	<.001	<.001	3	9
STOMACH	Regulation of smoothened signaling pathway →	+0.051	+0.593	.003	.008	3	9
SKIN	Telomere organization →	+0.055	+0.561	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,582 associations by consensus.

Constitutive heterochromatin formation by CARD8 expression — URINARY_TRACT

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