CARD8

Across TCGA cell cohorts, CARD8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible CARD8-associated genes across cancer lineages are MAGEB5, H4C7, and OR10G2. Each is linked with CARD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD8-to-partner and partner-to-CARD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CARD8-low versus CARD8-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD8→partner) and Y-score (partner→CARD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	H4C7 →	+0.389	+4.643	<.001	.008	3	1
LARGE_INTESTINE	OR10G2 →	+0.050	+4.562	<.001	<.001	3	1
SKIN	PABPC1L2A →	+0.029	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MAGEB5 by CARD8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →