CARD6

Across TCGA patient cohorts, CARD6 mutation is significantly associated with the RNA expression of many other genes, with 3,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD6-associated genes across cancer lineages are TSPAN7, CHAF1A, and RAD51. Each is linked with CARD6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CARD6-to-partner and partner-to-CARD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN7 grouped by CARD6-low versus CARD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD6→partner) and Y-score (partner→CARD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSPAN7 →	-1.148	-3.321	<.001	<.001	3	4
UCEC	CHAF1A →	+0.647	+2.384	<.001	<.001	3	4
UCEC	RAD51 →	+0.686	+1.928	<.001	<.001	3	4
LUAD	MARS1 →	+0.622	+3.214	.001	.009	3	3
LUAD	DSG1-AS1 →	+0.477	+3.250	.005	.001	3	3
UCEC	UHRF1 →	+0.894	+1.928	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,446 associations by consensus.

TSPAN7 by CARD6 expression — UCEC

Explore this box plot interactively →