CARD6

Across TCGA patient cohorts, CARD6 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD6-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and C-Raf. Each is linked with CARD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARD6-to-partner and partner-to-CARD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CARD6-low versus CARD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD6→partner) and Y-score (partner→CARD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.228	+3.169	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.122	+3.178	.003	.010	2	3
COAD	C-Raf →	+0.183	+3.000	.011	.035	3	2
UCEC	Caspase-8 →	-0.216	-2.432	.002	<.001	3	2
UCEC	eIF4E →	+0.186	+2.237	.001	<.001	3	2
UCEC	JNK2 →	+0.181	+1.398	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PCNA by CARD6 expression — UCEC

Explore this box plot interactively →