CARD6

Across TCGA cell cohorts, CARD6 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CARD6-associated genes across cancer lineages are SCYGR10, PF4V1, and IL4. Each is linked with CARD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD6-to-partner and partner-to-CARD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYGR10 grouped by CARD6-low versus CARD6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD6→partner) and Y-score (partner→CARD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCYGR10 →	+0.188	+3.232	.001	.008	3	2
OESOPHAGUS	PF4V1 →	+0.395	+3.836	.003	.004	3	1
OESOPHAGUS	IL4 →	+0.084	+3.392	<.001	.007	3	1
OESOPHAGUS	TSGA10IP →	+0.243	+3.836	.009	.004	3	1
LUNG_SCLC	C1QC →	+0.026	+3.584	<.001	.003	3	1
LUNG_SCLC	OR52D1 →	+0.073	+3.256	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SCYGR10 by CARD6 expression — LUNG_SCLC

Explore this box plot interactively →