CARD6

Across TCGA cell cohorts, CARD6 mutation is significantly associated with the mutation status of many other genes, with 4,244 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARD6-associated genes across cancer lineages are CTTNBP2, SLCO4C1, and ITPRID2. Each is linked with CARD6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CARD6-to-partner and partner-to-CARD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTTNBP2 grouped by CARD6-low versus CARD6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD6→partner) and Y-score (partner→CARD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTTNBP2 →	+2.047	+2.510	.004	.004	1	5
CNS	SLCO4C1 →	+5.347	+4.199	<.001	<.001	1	4
BLOOD_Lymphoma	ITPRID2 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Leukemia	ZBTB49 →	+3.523	+3.662	<.001	<.001	1	4
BLOOD_Lymphoma	POTEE →	+5.014	+5.584	.003	.003	1	4
BLOOD_Leukemia	ZNF521 →	+3.038	+3.347	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,244 associations by consensus.

CTTNBP2 by CARD6 expression — LARGE_INTESTINE

Explore this box plot interactively →