CARD17

Across TCGA patient cohorts, CARD17 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD17-associated genes across cancer lineages are RNA5SP410, RNU6-954P, and PLCE1P1. Each is linked with CARD17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD17-to-partner and partner-to-CARD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP410 grouped by CARD17-low versus CARD17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD17→partner) and Y-score (partner→CARD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP410 →	+0.926	+3.110	<.001	.002	3	2
LUSC	RNU6-954P →	+0.218	+4.496	.001	.007	3	2
LUSC	PLCE1P1 →	+0.431	+4.297	<.001	.009	3	2
BRCA	RN7SL673P →	+0.154	+8.055	<.001	.007	3	1
BRCA	RNA5SP27 →	+0.282	+7.731	<.001	.009	3	1
BRCA	SURF6P1 →	+0.049	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

RNA5SP410 by CARD17 expression — UCEC

Explore this box plot interactively →