CARD17

Across TCGA patient cohorts, CARD17 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD17-associated genes across cancer lineages are JNK2, PRAS40_pT246, and PCNA. Each is linked with CARD17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD17-to-partner and partner-to-CARD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CARD17-low versus CARD17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD17→partner) and Y-score (partner→CARD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.275	+3.000	.016	.037	3	1
UCEC	PRAS40_pT246 →	+0.274	+3.013	.005	.019	3	1
UCEC	PCNA →	+0.248	+3.000	.047	.037	2	1
UCEC	p27_pT198 →	+0.157	+3.000	.011	.037	1	1
UCEC	14-3-3_zeta →	-0.236	-2.973	.048	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by CARD17 expression — UCEC

Explore this box plot interactively →