Across TCGA patient cohorts, CARD16 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD16-associated genes across cancer lineages are EGFR_pY1068, Heregulin, and Notch1. Each is linked with CARD16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD16-to-partner and partner-to-CARD16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD16→partner) and Y-score (partner→CARD16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.365	-3.169	.005	.019	3	1
UCEC	Heregulin →	-0.147	-3.000	.022	.036	3	1
UCEC	Notch1 →	+0.266	+3.013	<.001	.018	3	1
UCEC	PDCD4 →	-0.573	-2.990	.020	.036	3	1
UCEC	TFRC →	+0.601	+3.321	.030	.010	3	1
UCEC	Caspase-8 →	-0.267	-2.973	.042	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

CARD16 survival (RNA) · tumor vs normal (RNA) · all CARD16 data types