CARD11-AS1

Across TCGA pan-cancer cohorts, CARD11-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated CARD11-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CARD11-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CARD11-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and UVM are the cancer types where CARD11-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.503	0.317	.002	69	view →
BLCA	OS	Quartile	II,III,IV	0.470	0.298	.001	68	view →
UVM	OS	Tertile	All	0.749	0.957	.009	60	view →
KIRC	OS	Quartile	All	0.540	0.716	<.001	49	view →
THCA	OS	Median	II,III,IV	0.741	0.975	<.001	26	view →
ACC	OS	Tertile	All	0.229	0.662	.007	21	view →
UCS	DFS	Tertile	II,III,IV	0.151	0.474	.013	18	view →
READ	DFS	Median	II,III,IV	0.214	0.654	.001	18	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →
CHOL	DFS	Quartile	III,IV	0.322	0.858	.038	9	view →
THYM	DFS	Tertile	III,IV	1.000	0.525	.031	6	view →
ESCA	DFS	Quartile	III,IV	0.645	0.245	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

CARD11-AS1–HNSC (OS)

Open the HNSC breakdown →