CAPZB

Across TCGA pan-cancer cohorts, CAPZB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CAPZB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CAPZB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CAPZB is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, PDAC, and CCRCC are the cancer types where CAPZB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPZB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.323	<.001	11	view →
PDAC	Female	All	+0.707	<.001	8	view →
CCRCC	All	II,III,IV	+0.088	.002	7	view →
LSCC	Male	II,III,IV	−0.142	<.001	6	view →
LUAD	All	All	+0.059	<.001	3	view →
HNSC	Female	IV	+0.165	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CAPZB–COAD

Open the COAD breakdown →