CAPZA3

Across TCGA patient cohorts, CAPZA3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPZA3-associated genes across cancer lineages are NF2, Ku80, and TFRC. Each is linked with CAPZA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPZA3-to-partner and partner-to-CAPZA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by CAPZA3-low versus CAPZA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZA3→partner) and Y-score (partner→CAPZA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF2 →	+0.189	+1.807	.021	.022	3	3
UCEC	Ku80 →	+0.233	+2.713	.028	.003	3	2
UCEC	TFRC →	+0.543	+2.000	.023	.032	3	2
UCEC	cIAP →	+0.131	+3.179	.034	.010	3	2
SKCM	eEF2 →	+0.257	+1.717	.013	.022	3	2
SKCM	Cyclin-D1 →	-0.159	-2.115	.022	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

NF2 by CAPZA3 expression — SKCM

Explore this box plot interactively →