CAPZA3

Across TCGA cell cohorts, CAPZA3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPZA3-associated genes across cancer lineages are RFPL3, CCDC172, and FABP12. Each is linked with CAPZA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZA3-to-partner and partner-to-CAPZA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by CAPZA3-low versus CAPZA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZA3→partner) and Y-score (partner→CAPZA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFPL3 →	+0.029	+3.510	.006	.003	3	1
LARGE_INTESTINE	CCDC172 →	+0.005	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	FABP12 →	+0.046	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PATE4 →	+0.041	+3.510	<.001	.003	3	1
LARGE_INTESTINE	DCANP1 →	+0.011	+3.347	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPATA48 →	+0.013	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RFPL3 by CAPZA3 expression — LARGE_INTESTINE

Explore this box plot interactively →