Across TCGA patient cohorts, CAPZA2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPZA2-associated genes across cancer lineages are 14-3-3_beta, Annexin_VII, and XBP1. Each is linked with CAPZA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZA2-to-partner and partner-to-CAPZA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZA2→partner) and Y-score (partner→CAPZA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.118	-2.973	.011	.035	3	1
UCEC	Annexin_VII →	-0.161	-2.990	.012	.036	3	1
UCEC	XBP1 →	-0.199	-3.459	.002	.005	3	1
UCEC	Chk2_pT68 →	-0.175	-2.584	.044	.011	3	1
UCEC	Di-Ras3 →	-0.138	-2.584	.046	.011	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

CAPZA2 survival (RNA) · tumor vs normal (RNA) · all CAPZA2 data types