CAPZA1

Across TCGA pan-cancer cohorts, CAPZA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CAPZA1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher CAPZA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CAPZA1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

GBM, LSCC, and OV are the cancer types where CAPZA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.368	0.745	<.001	20	view →
LSCC	DFS	Quartile	All	1.000	0.274	.004	10	view →
OV	DFS	Quartile	All	1.000	0.653	.040	8	view →
CCRCC	OS	Quartile	All	0.704	0.920	.014	8	view →
LUAD	OS	Quartile	III,IV	0.190	0.787	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CAPZA1–GBM (OS)

Open the GBM breakdown →