CAPRIN2

Across TCGA patient cohorts, CAPRIN2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CAPRIN2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Cyclin-B1, and EGFR_pY1068. Each is linked with CAPRIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPRIN2-to-partner and partner-to-CAPRIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CAPRIN2-low versus CAPRIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPRIN2→partner) and Y-score (partner→CAPRIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.324	-1.308	.017	.012	3	3
COAD	Cyclin-B1 →	+0.542	+2.178	.034	.035	3	3
UCEC	EGFR_pY1068 →	-0.199	-1.662	.008	.010	3	2
UCEC	JNK2 →	+0.263	+2.097	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.197	+1.512	.045	.017	3	2
COAD	PCNA →	+0.374	+3.330	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

p38-MAPK_pT180_Y182 by CAPRIN2 expression — UCEC

Explore this box plot interactively →