CAPRIN1

Across TCGA patient cohorts, CAPRIN1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPRIN1-associated genes across cancer lineages are MEK1, MSH6, and Bim. Each is linked with CAPRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPRIN1-to-partner and partner-to-CAPRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CAPRIN1-low versus CAPRIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPRIN1→partner) and Y-score (partner→CAPRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.280	+1.807	.037	.025	3	2
UCEC	MSH6 →	-0.362	-2.222	.002	.009	3	2
COAD	Bim →	+0.269	+3.178	.043	.010	3	1
UCEC	p62 Lck ligand →	+0.282	+1.847	.018	.008	3	1
UCEC	VHL →	-0.858	-1.847	<.001	.008	3	1
UCEC	ATM →	-0.403	-1.502	.015	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by CAPRIN1 expression — UCEC

Explore this box plot interactively →