CAPNS2

Across TCGA patient cohorts, CAPNS2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPNS2-associated genes across cancer lineages are MEK1, N-Ras, and PDK1_pS241. Each is linked with CAPNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPNS2-to-partner and partner-to-CAPNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CAPNS2-low versus CAPNS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPNS2→partner) and Y-score (partner→CAPNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.408	+3.169	.042	.020	3	1
UCEC	N-Ras →	-0.129	-3.156	.048	.020	3	1
UCEC	PDK1_pS241 →	+0.196	+3.183	.036	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.867	+2.827	.007	.035	3	1
UCEC	Shc_pY317 →	-0.259	-3.169	.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by CAPNS2 expression — UCEC

Explore this box plot interactively →