CAPNS1

Across TCGA pan-cancer cohorts, CAPNS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CAPNS1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CAPNS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CAPNS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where CAPNS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	18	view →
HNSC	DFS	Tertile	III,IV	0.925	0.670	.007	9	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
LUAD	DFS	Tertile	All	0.915	0.516	.039	4	view →
GBM	DFS	Quartile	All	0.597	0.833	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CAPNS1–CCRCC (DFS)

Open the CCRCC breakdown →