CAPNS1

Across TCGA patient cohorts, CAPNS1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPNS1-associated genes across cancer lineages are MEK1, MSH2, and SF2. Each is linked with CAPNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPNS1-to-partner and partner-to-CAPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CAPNS1-low versus CAPNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPNS1→partner) and Y-score (partner→CAPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.575	+3.459	.001	.005	3	1
UCEC	MSH2 →	-0.426	-2.973	<.001	.035	3	1
UCEC	SF2 →	-0.132	-2.308	.016	.036	3	1
UCEC	IGFBP2 →	-1.237	-2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by CAPNS1 expression — UCEC

Explore this box plot interactively →