CAPN9

Across TCGA patient cohorts, CAPN9 mutation is significantly associated with the RNA expression of many other genes, with 4,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN9-associated genes across cancer lineages are ELMO2P1, SNRPD1, and SCNN1B. Each is linked with CAPN9 in more than 3 cancer types. Because this analysis shows association rather than direction, both CAPN9-to-partner and partner-to-CAPN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELMO2P1 grouped by CAPN9-low versus CAPN9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN9→partner) and Y-score (partner→CAPN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELMO2P1 →	+0.078	+1.406	.008	.007	3	4
UCEC	SNRPD1 →	+0.398	+1.654	.001	.002	3	3
UCEC	SCNN1B →	-1.345	-1.643	<.001	.003	3	3
UCEC	CDC7 →	+0.640	+2.400	.001	<.001	3	3
UCEC	MTHFD1 →	+0.542	+2.523	<.001	<.001	3	3
SKCM	SF3A2 →	+0.398	+2.877	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,209 associations by consensus.

ELMO2P1 by CAPN9 expression — UCEC

Explore this box plot interactively →