CAPN9

Across TCGA cell cohorts, CAPN9 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN9-associated genes across cancer lineages are FOXB2, RAB3A, and PCCB. Each is linked with CAPN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN9-to-partner and partner-to-CAPN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXB2 grouped by CAPN9-low versus CAPN9-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN9→partner) and Y-score (partner→CAPN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FOXB2 →	+0.042	+5.169	<.001	.005	3	2
LARGE_INTESTINE	RAB3A →	+1.314	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PCCB →	+0.761	+3.125	<.001	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.099	+2.560	<.001	.009	3	1
LARGE_INTESTINE	C10orf53 →	+0.014	+3.310	<.001	<.001	3	1
LARGE_INTESTINE	KRTAP19-5 →	+0.156	+2.669	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FOXB2 by CAPN9 expression — BREAST

Explore this box plot interactively →