Across TCGA pan-cancer cohorts, CAPN8 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CAPN8 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CAPN8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CAPN8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC and LUAD are the cancer types where CAPN8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.958	0.723	.001	52	view →
LUAD	DFS	Median	II,III,IV	0.911	0.758	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: CAPN8 tumor-vs-normal RNA expression · all CAPN8 data types