Across TCGA patient cohorts, CAPN8 protein abundance is significantly associated with the RNA expression of many other genes, with 2,987 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CAPN8-associated genes across cancer lineages are VSIG2, TSPAN1, and PIK3C2B. Each is linked with CAPN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN8-to-partner and partner-to-CAPN8 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN8→partner) and Y-score (partner→CAPN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VSIG2 →	+1.905	+0.990	<.001	<.001	3	3
BRCA	TSPAN1 →	+3.367	+0.923	.001	.006	3	2
BRCA	PIK3C2B →	+0.882	+0.901	<.001	.008	3	2
BRCA	LGALS9C →	+1.372	+0.874	<.001	.008	3	2
BRCA	SLC2A10 →	+1.927	+0.899	.002	.008	3	2
LSCC	LMO7 →	+0.668	+0.390	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,987 associations by consensus.

Exploration

CAPN8 survival (RNA) · tumor vs normal (RNA) · all CAPN8 data types