Across TCGA patient cohorts, CAPN8 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN8-associated genes across cancer lineages are PKC-delta_pS664, 14-3-3_beta, and EGFR_pY1068. Each is linked with CAPN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN8-to-partner and partner-to-CAPN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN8→partner) and Y-score (partner→CAPN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.128	-3.700	.003	.001	3	2
UCEC	14-3-3_beta →	-0.113	-2.673	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.328	-2.247	<.001	.001	3	1
UCEC	eIF4E →	+0.196	+1.807	.011	.025	3	1
UCEC	ERK2 →	+0.206	+2.115	.003	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.222	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

CAPN8 survival (RNA) · tumor vs normal (RNA) · all CAPN8 data types