Across TCGA cell cohorts, CAPN8 mutation is significantly associated with the mutation status of many other genes, with 2,626 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN8-associated genes across cancer lineages are CRACD, PRR12, and ZNF831. Each is linked with CAPN8 in more than 3 cancer types. Because this analysis shows association rather than direction, both CAPN8-to-partner and partner-to-CAPN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN8→partner) and Y-score (partner→CAPN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRACD →	+2.825	+3.847	.001	.001	1	4
BLOOD_Lymphoma	PRR12 →	+3.025	+3.754	.006	.006	1	4
BLOOD_Leukemia	ZNF831 →	+3.115	+4.080	.001	.001	1	4
LARGE_INTESTINE	AMOTL2 →	+2.643	+2.321	.004	.004	1	4
LARGE_INTESTINE	SEC24B →	+1.807	+2.179	.004	.004	1	4
BLOOD_Leukemia	PCDHGA1 →	+3.063	+3.498	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,626 associations by consensus.

Exploration

CAPN8 survival (RNA) · tumor vs normal (RNA) · all CAPN8 data types