CAPN7

Across TCGA patient cohorts, CAPN7 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN7-associated genes across cancer lineages are p27_pT198, TFRC, and 14-3-3_beta. Each is linked with CAPN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN7-to-partner and partner-to-CAPN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CAPN7-low versus CAPN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN7→partner) and Y-score (partner→CAPN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.074	+2.459	.045	.019	3	2
UCEC	TFRC →	+0.456	+2.459	.013	.018	3	2
UCEC	14-3-3_beta →	-0.099	-2.780	.004	.003	3	1
UCEC	eEF2 →	+0.331	+1.736	.007	.007	3	1
UCEC	EGFR_pY1068 →	-0.292	-2.087	<.001	.005	3	1
UCEC	EGFR →	-0.130	-2.000	.019	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p27_pT198 by CAPN7 expression — UCEC

Explore this box plot interactively →