CAPN6

Across TCGA pan-cancer cohorts, CAPN6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CAPN6 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CAPN6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CAPN6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where CAPN6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.543	0.278	.002	39	view →
HNSC	DFS	Quartile	All	0.646	0.937	.037	2	view →
CCRCC	DFS	Median	All	0.785	0.557	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CAPN6–PDAC (DFS)

Open the PDAC breakdown →