CAPN6

Across TCGA cell cohorts, CAPN6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CAPN6-associated genes across cancer lineages are KRTAP21-1, ASB17, and OXT. Each is linked with CAPN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN6-to-partner and partner-to-CAPN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-1 grouped by CAPN6-low versus CAPN6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN6→partner) and Y-score (partner→CAPN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP21-1 →	+0.050	+6.022	<.001	.001	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
LUNG_NSCLC_LUAD	OXT →	+0.252	+3.215	.005	.007	3	1
LUNG_NSCLC_LUAD	CT45A6 →	+0.068	+3.604	.008	.004	3	1
LUNG_NSCLC_LUAD	CDCP2 →	+0.017	+3.347	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP21-1 by CAPN6 expression — SKIN

Explore this box plot interactively →