CAPN15

Across TCGA patient cohorts, CAPN15 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN15-associated genes across cancer lineages are Caspase-7-cleavedD198, PDCD4, and PKC-a. Each is linked with CAPN15 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN15-to-partner and partner-to-CAPN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CAPN15-low versus CAPN15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN15→partner) and Y-score (partner→CAPN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.972	+2.700	<.001	.005	3	3
UCEC	PDCD4 →	-0.363	-2.000	.049	.010	3	2
UCEC	PKC-a →	+0.346	+2.000	.029	.010	3	2
UCEC	Di-Ras3 →	-0.199	-2.502	<.001	.002	3	2
UCEC	ERK2 →	+0.173	+2.459	.022	.019	3	1
UCEC	Ku80 →	+0.220	+1.594	.017	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by CAPN15 expression — UCEC

Explore this box plot interactively →