CAPN15

Across TCGA cell cohorts, CAPN15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,653 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CAPN15-associated GO terms across cancer lineages are Negative regulation of translational initiation, CAMP/PKA signal transduction, and rRNA pseudouridine synthesis. Each is linked with CAPN15 in more than 14 cancer types. Because this analysis shows association rather than direction, both CAPN15-to-partner and partner-to-CAPN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translational initiation grouped by CAPN15-low versus CAPN15-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN15→partner) and Y-score (partner→CAPN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of translational initiation →	+0.119	+1.207	<.001	<.001	3	15
BONE	CAMP/PKA signal transduction →	+0.200	+1.111	<.001	<.001	3	14
BONE	rRNA pseudouridine synthesis →	+0.140	+1.526	<.001	<.001	3	14
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.195	+1.316	<.001	<.001	3	14
URINARY_TRACT	Enzyme-directed rRNA pseudouridine synthesis →	+0.127	+0.970	.002	.008	2	14
BONE	Calcium-independent cell-matrix adhesion →	+0.271	+1.575	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,653 associations by consensus.

Negative regulation of translational initiation by CAPN15 expression — BONE

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