Across TCGA patient cohorts, CAPN14 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN14-associated genes across cancer lineages are HER3_pY1289, mTOR_pS2448, and PDCD4. Each is linked with CAPN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN14-to-partner and partner-to-CAPN14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN14→partner) and Y-score (partner→CAPN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.077	+1.894	.009	.030	3	2
UCEC	mTOR_pS2448 →	-0.112	-1.980	.030	.030	3	2
UCEC	PDCD4 →	-0.496	-2.070	.002	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.724	+1.736	<.001	.007	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.070	.006	.001	3	1
UCEC	EGFR_pY1173 →	+0.084	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

CAPN14 survival (RNA) · tumor vs normal (RNA) · all CAPN14 data types