Across TCGA cell cohorts, CAPN14 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CAPN14-associated genes across cancer lineages are FAM205A, OTOR, and OR10A4. Each is linked with CAPN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN14-to-partner and partner-to-CAPN14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN14→partner) and Y-score (partner→CAPN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
OVARY	OTOR →	+0.087	+3.791	<.001	.007	3	1
OVARY	OR10A4 →	+0.035	+4.095	<.001	.003	3	1
OVARY	DMRTC1B →	+0.198	+3.862	<.001	.005	3	1
OVARY	TBX5 →	+0.162	+4.095	<.001	.003	3	1
BREAST	KRTAP4-12 →	+0.046	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

CAPN14 survival (RNA) · tumor vs normal (RNA) · all CAPN14 data types