CAPN13

Across TCGA patient cohorts, CAPN13 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN13-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and p38-MAPK_pT180_Y182. Each is linked with CAPN13 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN13-to-partner and partner-to-CAPN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CAPN13-low versus CAPN13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN13→partner) and Y-score (partner→CAPN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.758	+2.189	<.001	.001	3	3
UCEC	4E-BP1 →	+0.316	+3.700	<.001	.001	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.243	-1.637	.017	.001	3	2
UCEC	PDCD4 →	-0.440	-1.459	.003	.012	3	2
UCEC	STAT5a →	+0.293	+1.222	.024	.035	3	2
UCEC	TFRC →	+0.534	+2.584	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by CAPN13 expression — UCEC

Explore this box plot interactively →