CAPN13

Across TCGA cell cohorts, CAPN13 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN13-associated genes across cancer lineages are OR2G6, CTXN3, and LALBA. Each is linked with CAPN13 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN13-to-partner and partner-to-CAPN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2G6 grouped by CAPN13-low versus CAPN13-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN13→partner) and Y-score (partner→CAPN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR2G6 →	+0.146	+4.247	.002	<.001	3	2
LARGE_INTESTINE	CTXN3 →	+0.411	+3.196	<.001	.007	3	2
PANCREAS	LALBA →	+0.024	+4.786	<.001	.001	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
BLOOD_Lymphoma	SLC2A2 →	+0.039	+3.192	.001	.008	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

OR2G6 by CAPN13 expression — STOMACH

Explore this box plot interactively →