CAPN12

Across TCGA patient cohorts, CAPN12 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN12-associated genes across cancer lineages are Di-Ras3, eEF2, and EGFR_pY1068. Each is linked with CAPN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN12-to-partner and partner-to-CAPN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by CAPN12-low versus CAPN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN12→partner) and Y-score (partner→CAPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.134	-3.308	.025	.009	3	2
UCEC	eEF2 →	+0.327	+2.999	.023	.035	3	1
UCEC	EGFR_pY1068 →	-0.222	-2.415	.027	.003	3	1
UCEC	eIF4E →	+0.196	+3.013	.020	.018	3	1
UCEC	ERK2 →	+0.171	+2.321	.027	.034	3	1
UCEC	Ku80 →	+0.240	+1.920	.011	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Di-Ras3 by CAPN12 expression — UCEC

Explore this box plot interactively →