CAPN12

Across TCGA cell cohorts, CAPN12 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CAPN12-associated genes across cancer lineages are WNT8A, LRAT, and OR11H1. Each is linked with CAPN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN12-to-partner and partner-to-CAPN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNT8A grouped by CAPN12-low versus CAPN12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN12→partner) and Y-score (partner→CAPN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WNT8A →	+0.013	+3.345	<.001	.007	3	1
BLOOD_Leukemia	LRAT →	+0.235	+3.816	<.001	.002	3	1
BLOOD_Leukemia	OR11H1 →	+0.058	+3.786	<.001	.002	3	1
BLOOD_Leukemia	LRRIQ1 →	+0.322	+3.615	<.001	.004	3	1
BLOOD_Leukemia	TRPC3 →	+0.636	+3.345	<.001	.009	3	1
BLOOD_Leukemia	HABP2 →	+0.433	+3.007	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

WNT8A by CAPN12 expression — SKIN

Explore this box plot interactively →