CAPN11

Across TCGA pan-cancer cohorts, CAPN11 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CAPN11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAPN11 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CAPN11 is over-expressed in tumor.

HNSC, LUAD, and COAD are the cancer types where CAPN11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPN11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.460	<.001	11	view →
LUAD	All	III,IV	+0.755	<.001	9	view →
COAD	Male	II,III,IV	+0.520	<.001	9	view →
CCRCC	Male	All	+0.313	<.001	8	view →
LSCC	Male	II,III,IV	+0.364	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CAPN11–HNSC

Open the HNSC breakdown →