CAPN11

Across TCGA patient cohorts, CAPN11 mutation is significantly associated with the RNA expression of many other genes, with 2,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN11-associated genes across cancer lineages are MSANTD3, KRT19P1, and TIMM50. Each is linked with CAPN11 in more than 3 cancer types. Because this analysis shows association rather than direction, both CAPN11-to-partner and partner-to-CAPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSANTD3 grouped by CAPN11-low versus CAPN11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN11→partner) and Y-score (partner→CAPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MSANTD3 →	+0.616	+2.424	<.001	.001	3	4
LIHC	KRT19P1 →	+0.211	+3.787	<.001	.009	3	3
SKCM	TIMM50 →	+0.596	+3.807	<.001	<.001	3	3
UCEC	CDT1 →	+0.676	+2.233	<.001	<.001	3	3
UCEC	TIMM44 →	+0.438	+2.233	<.001	<.001	3	3
UCEC	MYCL →	-0.869	-2.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,245 associations by consensus.

MSANTD3 by CAPN11 expression — SKCM

Explore this box plot interactively →