CAPN11

Across TCGA patient cohorts, CAPN11 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN11-associated genes across cancer lineages are Caspase-8, ERK2, and CDK1. Each is linked with CAPN11 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN11-to-partner and partner-to-CAPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by CAPN11-low versus CAPN11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN11→partner) and Y-score (partner→CAPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.234	-2.195	.011	.009	3	3
SKCM	ERK2 →	+0.217	+1.700	.014	.043	3	2
SKCM	CDK1 →	+0.150	+2.321	.041	.033	3	2
UCEC	Fibronectin →	-0.299	-2.312	.013	.005	3	2
UCEC	p62 Lck ligand →	+0.468	+2.736	<.001	<.001	3	2
UCEC	PCNA →	+0.227	+1.847	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-8 by CAPN11 expression — UCEC

Explore this box plot interactively →