CAPN11

Across TCGA cell cohorts, CAPN11 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CAPN11-associated genes across cancer lineages are H4C7, UBQLN3, and EDDM3B. Each is linked with CAPN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN11-to-partner and partner-to-CAPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C7 grouped by CAPN11-low versus CAPN11-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN11→partner) and Y-score (partner→CAPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	H4C7 →	+0.389	+4.643	<.001	.008	3	1
BREAST	UBQLN3 →	+0.023	+3.672	<.001	.006	3	1
BREAST	EDDM3B →	+0.025	+3.672	<.001	.006	3	1
BREAST	OR52L1 →	+0.016	+3.672	<.001	.006	3	1
BREAST	OR8K3 →	+0.065	+4.196	<.001	.006	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

H4C7 by CAPN11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →