CAPN1

Across TCGA pan-cancer cohorts, CAPN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CAPN1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CAPN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CAPN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where CAPN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.963	0.781	.003	59	view →
CCRCC	DFS	Median	All	1.000	0.729	.017	28	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Median	All	0.933	1.000	.016	4	view →
LSCC	OS	Quartile	II,III,IV	0.614	0.933	.015	4	view →
LUAD	OS	Quartile	All	0.759	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CAPN1–HNSC (OS)

Open the HNSC breakdown →